Will Kahtoola crampons and running/trail shoes do?
I used Kahtoola Microspikes on running shoes, which performed well. I have zero experience with Kahtoola crampons and trail running shoes, but will venture this opinion: Microspikes have a heavy duty rubber collar that fits over the shoe and steel chain-link meshing beneath the shoe, which is well attached to the rubber collar and provides solid support for the microspikes on the shoe. In other words, no movement of the microspike while on the shoe. Crampons appear to be constructed for boots, and may not attached with the same reliability as microspikes onto a running shoe. Due to the gradient of Skyline, I cannot envision a senario where crampons would be a better choice than microspikes. Microspikes will always meet the minimum safety threshold for me. Again, just an opinion.
Not that this needs to be stated, but testing crampons on Skyline probably isn't the best idea.
Best success out there!